Antiproliferative evaluation of various aminoquinoline derivatives.
Identifieur interne : 000A72 ( Main/Exploration ); précédent : 000A71; suivant : 000A73Antiproliferative evaluation of various aminoquinoline derivatives.
Auteurs : Branka Zorc [Croatie] ; Zrinka Raji [Croatie] ; Ivana Perkovi [Croatie]Source :
- Acta pharmaceutica (Zagreb, Croatia) [ 1846-9558 ] ; 2019.
Descripteurs français
- KwdFr :
- Aminoquinoléines (pharmacologie), Antinéoplasiques (pharmacologie), Cellules HCT116, Cellules MCF-7, Humains, Lignée cellulaire tumorale, Primaquine (pharmacologie), Prolifération cellulaire (), Tumeurs du côlon (traitement médicamenteux), Tumeurs du poumon (traitement médicamenteux), Tumeurs du sein (traitement médicamenteux), Urée (pharmacologie).
- MESH :
- pharmacologie : Aminoquinoléines, Antinéoplasiques, Primaquine, Urée.
- traitement médicamenteux : Tumeurs du côlon, Tumeurs du poumon, Tumeurs du sein.
- Cellules HCT116, Cellules MCF-7, Humains, Lignée cellulaire tumorale, Prolifération cellulaire.
English descriptors
- KwdEn :
- Aminoquinolines (pharmacology), Antineoplastic Agents (pharmacology), Breast Neoplasms (drug therapy), Cell Line, Tumor, Cell Proliferation (drug effects), Colonic Neoplasms (drug therapy), HCT116 Cells, Humans, Lung Neoplasms (drug therapy), MCF-7 Cells, Primaquine (pharmacology), Urea (pharmacology).
- MESH :
- chemical , pharmacology : Aminoquinolines, Antineoplastic Agents, Primaquine, Urea.
- drug effects : Cell Proliferation.
- drug therapy : Breast Neoplasms, Colonic Neoplasms, Lung Neoplasms.
- Cell Line, Tumor, HCT116 Cells, Humans, MCF-7 Cells.
Abstract
Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a-f, primaquine bis-ureas 2a-f, chloroquine fumardiamides 3a-f and mefloquine fumardiamides 4a-f. Their antiproliferative activities against breast adeno-carcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.
DOI: 10.2478/acph-2019-0048
PubMed: 31639093
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000027
- to stream PubMed, to step Curation: 000027
- to stream PubMed, to step Checkpoint: 000068
- to stream Ncbi, to step Merge: 000B29
- to stream Ncbi, to step Curation: 000B29
- to stream Ncbi, to step Checkpoint: 000B29
- to stream Main, to step Merge: 000A72
- to stream Main, to step Curation: 000A72
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antiproliferative evaluation of various aminoquinoline derivatives.</title><author><name sortKey="Zorc, Branka" sort="Zorc, Branka" uniqKey="Zorc B" first="Branka" last="Zorc">Branka Zorc</name><affiliation wicri:level="1"><nlm:affiliation>University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb, Croatia.</nlm:affiliation><country xml:lang="fr">Croatie</country><wicri:regionArea>University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb</wicri:regionArea><wicri:noRegion>Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Raji, Zrinka" sort="Raji, Zrinka" uniqKey="Raji Z" first="Zrinka" last="Raji">Zrinka Raji</name><affiliation wicri:level="1"><nlm:affiliation>University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb, Croatia.</nlm:affiliation><country xml:lang="fr">Croatie</country><wicri:regionArea>University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb</wicri:regionArea><wicri:noRegion>Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Perkovi, Ivana" sort="Perkovi, Ivana" uniqKey="Perkovi I" first="Ivana" last="Perkovi">Ivana Perkovi</name><affiliation wicri:level="1"><nlm:affiliation>University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb, Croatia.</nlm:affiliation><country xml:lang="fr">Croatie</country><wicri:regionArea>University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb</wicri:regionArea><wicri:noRegion>Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31639093</idno><idno type="pmid">31639093</idno><idno type="doi">10.2478/acph-2019-0048</idno><idno type="wicri:Area/PubMed/Corpus">000027</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000027</idno><idno type="wicri:Area/PubMed/Curation">000027</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000027</idno><idno type="wicri:Area/PubMed/Checkpoint">000068</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000068</idno><idno type="wicri:Area/Ncbi/Merge">000B29</idno><idno type="wicri:Area/Ncbi/Curation">000B29</idno><idno type="wicri:Area/Ncbi/Checkpoint">000B29</idno><idno type="wicri:Area/Main/Merge">000A72</idno><idno type="wicri:Area/Main/Curation">000A72</idno><idno type="wicri:Area/Main/Exploration">000A72</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antiproliferative evaluation of various aminoquinoline derivatives.</title><author><name sortKey="Zorc, Branka" sort="Zorc, Branka" uniqKey="Zorc B" first="Branka" last="Zorc">Branka Zorc</name><affiliation wicri:level="1"><nlm:affiliation>University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb, Croatia.</nlm:affiliation><country xml:lang="fr">Croatie</country><wicri:regionArea>University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb</wicri:regionArea><wicri:noRegion>Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Raji, Zrinka" sort="Raji, Zrinka" uniqKey="Raji Z" first="Zrinka" last="Raji">Zrinka Raji</name><affiliation wicri:level="1"><nlm:affiliation>University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb, Croatia.</nlm:affiliation><country xml:lang="fr">Croatie</country><wicri:regionArea>University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb</wicri:regionArea><wicri:noRegion>Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb</wicri:noRegion></affiliation></author><author><name sortKey="Perkovi, Ivana" sort="Perkovi, Ivana" uniqKey="Perkovi I" first="Ivana" last="Perkovi">Ivana Perkovi</name><affiliation wicri:level="1"><nlm:affiliation>University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb, Croatia.</nlm:affiliation><country xml:lang="fr">Croatie</country><wicri:regionArea>University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb</wicri:regionArea><wicri:noRegion>Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb</wicri:noRegion></affiliation></author></analytic><series><title level="j">Acta pharmaceutica (Zagreb, Croatia)</title><idno type="eISSN">1846-9558</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aminoquinolines (pharmacology)</term><term>Antineoplastic Agents (pharmacology)</term><term>Breast Neoplasms (drug therapy)</term><term>Cell Line, Tumor</term><term>Cell Proliferation (drug effects)</term><term>Colonic Neoplasms (drug therapy)</term><term>HCT116 Cells</term><term>Humans</term><term>Lung Neoplasms (drug therapy)</term><term>MCF-7 Cells</term><term>Primaquine (pharmacology)</term><term>Urea (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aminoquinoléines (pharmacologie)</term><term>Antinéoplasiques (pharmacologie)</term><term>Cellules HCT116</term><term>Cellules MCF-7</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Primaquine (pharmacologie)</term><term>Prolifération cellulaire ()</term><term>Tumeurs du côlon (traitement médicamenteux)</term><term>Tumeurs du poumon (traitement médicamenteux)</term><term>Tumeurs du sein (traitement médicamenteux)</term><term>Urée (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Aminoquinolines</term><term>Antineoplastic Agents</term><term>Primaquine</term><term>Urea</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Breast Neoplasms</term><term>Colonic Neoplasms</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Aminoquinoléines</term><term>Antinéoplasiques</term><term>Primaquine</term><term>Urée</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs du côlon</term><term>Tumeurs du poumon</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>HCT116 Cells</term><term>Humans</term><term>MCF-7 Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules HCT116</term><term>Cellules MCF-7</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Prolifération cellulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a-f, primaquine bis-ureas 2a-f, chloroquine fumardiamides 3a-f and mefloquine fumardiamides 4a-f. Their antiproliferative activities against breast adeno-carcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.</div></front></TEI><affiliations><list><country><li>Croatie</li></country></list><tree><country name="Croatie"><noRegion><name sortKey="Zorc, Branka" sort="Zorc, Branka" uniqKey="Zorc B" first="Branka" last="Zorc">Branka Zorc</name></noRegion><name sortKey="Perkovi, Ivana" sort="Perkovi, Ivana" uniqKey="Perkovi I" first="Ivana" last="Perkovi">Ivana Perkovi</name><name sortKey="Raji, Zrinka" sort="Raji, Zrinka" uniqKey="Raji Z" first="Zrinka" last="Raji">Zrinka Raji</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A72 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A72 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:31639093
|texte= Antiproliferative evaluation of various aminoquinoline derivatives.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31639093" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |